Skip to Content Skip to Navigation Accessibility Policy Click to login to your Account
Keep the Greens Coming! Subscribe, Save 20% and Get a Free Shaker Bottle Subscribe Now
Bulletproof Bulletproof is a food and beverage company, known for Bulletproof Coffee and products that fuel your mind and body.
Menu
Shop
Shop
Coffee
Ground Whole Bean Single-Serve Pods Starter Kits Cold Brew Creamers & Mix-Ins View all
MCT Oil
Brain Octane Oil MCT Oil View all
Proteins
Collagen Protein Collagen Protein Bars Collagen Protein Plus Support View all
Food & Drink
Protein Bars Cold Brew Chocolate Bars View all
Supplements
Greens Gummy Vitamins Mood & Memory Performance & Immunity Detox & Gut Health Sleep Support View all
Other
Tech Coffee Mugs & Bottles Books View all
Shop All Products
Subscribe & Save 20% + Free Shipping over $35
Learn More
Health Upgrades
Health Upgrades
Guides
Immune Boost Sleep Hacks Brain Upgrades Weight Loss & Diet Anti-Aging View all
Supplements
Greens Gummy Vitamins Mood & Memory Performance & Immunity Detox & Gut Health Sleep Support View all
Shop All Products
Keep the Greens Coming
Subscribe and Save
Keep the Greens Coming

Save 20% + get a free shaker when you subscribe to Greens

Shop Now
Subscribe & Save 20% + Free Shipping over $35
Learn More
Recipes
Recipes
Recipes
Snacks Breakfasts Main Dishes Beverages Desserts Keto Paleo View all
Shop All Ingredients
Bulletproof Coffee Recipe
FEATURED RECIPE
BULLETPROOF COFFEE: THE OFFICIAL RECIPE
VIEW RECIPE
Beginner keto cookbook
Free eCookbook
21 Easy Recipes to Fuel Your Keto Journey
Download Now
Subscribe & Save 20% + Free Shipping over $35
Learn More
Learn
Learn
Where to Start
About Bulletproof Bulletproof for Beginners Bulletproof Coffee: The Official Recipe What makes Bulletproof Coffee Beans Different? What are MCT Oils? What is Collagen Protein? Starter Kits Newsletters & Guides
Keto Kickstart
Keto Beginners Guide Calculating Carbs Alcohol Guide Keto Foods List Dirty vs. Clean Keto Weight Loss Troubleshooting Keto Recipes
Bulletproof Blog
Diet Recipes Coffee Supplements Sleep Gut Health Lifestyle View all
Books
Game Changers The Bulletproof Diet Bulletproof The Cookbook View all
Shop All Products
Subscribe & Save 20% + Free Shipping over $35
Learn More
Subscribe & Save 20%
Deals
Deals Subscribe & Save 20% expand/collapse Store Locator Account Cart
Deals Subscribe & Save 20% expand/collapse Account Cart
Search

Share

product
https://www.bulletproof.com/supplements/age-immune/anti-aging-supplements/ article-31449 13 Anti-Aging Supplements to Turn You Into Benjamin Button https://www.bulletproof.com/wp-content/uploads/2020/12/Blog_Template_0017_Collagen-Protein-300x160.jpg 1 USD InStock Age & Immune Support Anti Aging Biohacking Longevity Nootropics Supplements NUT06-00010 NUT06-00012 NUT08-00003 NUT08-00011 NUT08-00012 NUT08-00014 NUT08-00015 NUT08-00016 NUT08-00020 NUT08-00023 NUT08-00025 NUT08-00026 NUT08-00027 NUT08-00029 NUT08-00030 NUT08-00031 NUT08-00032 NUT08-00033 article
Home / Supplements / Age & Immune Support
|June 15, 2021

13 Anti-Aging Supplements to Turn You Into Benjamin Button

By Dave Asprey
Reviewed by Emily Gonzalez, ND for Scientific Accuracy

13 Anti-Aging Supplements to Turn You Into Benjamin Button

  • I plan to live to 180, and my anti-aging supplement stack is one of the ways I’m going to make that happen.
  • Below, you’ll find 13 of the best anti-aging supplements to help you turn back the clock. Two things you’ll notice with almost all of these recommendations is that they increase mitochondrial function and protect your cells.
  • You can get those same results from other actions, like improving your sleep quality and eating low-toxin, nutrient-dense foods. Longevity supplements just give your brain, body, and cells an extra edge.

It’s no secret that I plan to live 180, and my anti-aging supplement stack is one of the ways I’m going to make that happen. Too many people think that aging involves forgetting your name and leaving your car keys in the fridge. It doesn’t have to be that way.

Specific anti-aging supplements help you turn back the clock so you can keep kicking butt and taking names for years to come. Here are my top recommendations to keep your brain going strong.

13 best anti-aging supplements

  1. Fisetin
  2. Collagen Protein
  3. Nicotinamide riboside
  4. PQQ
  5. Acetyl-L-carnitine
  6. Whey protein
  7. Polyphenols
  8. KetoPrime
  9. D-Ribose
  10. Zinc and copper
  11. Vitamins A-D-K
  12. Curcumin
  13. Apigenin

Read on for details on how these anti-aging supplements help you turn back the clock:

1. Fisetin

Strawberries abundant in fisetin

Fisetin is a plant chemical with profound antioxidant properties. Like other antioxidants, it helps protect your cells from free radicals. Why does that matter? Free radicals are caused by oxidative stress from factors like your diet, environment and sleep routine (or lack thereof). Over time, free radicals can impair cellular function, contribute to cellular damage and accelerate the effects of aging.

That’s why you want plenty of diverse antioxidants in your diet—they help banish free radicals and keep you in fighting shape.

How to take it: Bulletproof Smart Mode contains fisetin, plus a blend of cognitive-enhancing ingredients for total mental clarity. Fisetin is also found naturally in apples, persimmons, onions, and other plants.[1] You can get an abundant dose of fisetin in strawberries. Try this Bulletproof Strawberry Milkshake With Collagen Protein. Speaking of collagen protein…

2. Collagen protein

Bowl of beef broth for natural collagen

Collagen supplements may seem like an obvious addition to your anti-aging supplement stack, but it’s worth repeating because collagen is the most abundant protein in the body. It gives structure to your skin, bones, muscles and connective tissue. It reduces fine lines and wrinkles, and improves the elasticity of your skin.[2]

Collagen protein has too many benefits to keep it out of your anti-aging supplement stack. You produce less collagen as you age, so you want to get plenty of it in your diet. Collagen is naturally found in bone broth; pork, salmon and chicken skins; egg yolk and eggshell membranes; and pieces of meat like tendon, tripe and oxtail.

How to take it: You probably don’t eat enough of it, so use a collagen peptides supplement from grass-fed cows. Bulletproof Collagen Protein provides building blocks to support healthy skin, bones and joints, and it mixes easily into coffee and smoothies.

3. Nicotinamide riboside

Ampules of Unfair Advantage

One thing you’ll notice with almost all of these recommendations is that they increase the performance of your mitochondria—you know, the powerhouses of your cells. Nicotinamide riboside, a form of vitamin B, is a great longevity supplement. It protects your brain from toxins and stress and increases the ratio of two essential compounds called NAD+ and NADH.[3] [4] Your body uses NAD+ to protect your cells, maintain healthy sleep cycles and repair damaged DNA.

How to take it: In my experience using nicotinamide riboside, I found that you need to take a lot of it, like 1-2 grams, in order to really feel an effect. If the cost of nicotinamide riboside is prohibitive, you have other options. We rigorously selected the formulation in Bulletproof Unfair Advantage to support mitochondrial efficiency with CoQ10 and PQQ.

4. PQQ

PQQ molecule concept

Pyrroloquinoline quinone, or PQQ, is at the forefront of anti-aging science. It’s a micronutrient that acts as a potent antioxidant, protecting your cells from damaging free radicals and supporting your brain and heart. Studies show that PQQ supports learning and memory, protects your heart, and supports a healthy inflammation response.[5] [6] [7]

It’s naturally found in some foods like green tea and green peppers,[8] but to reap its anti-aging benefits, take it in supplement form so you get a high enough dose that actually absorbs into your bloodstream.

How to take it: The main ingredient in Bulletproof Unfair Advantage is ActivePQQ, which is specifically designed to improve PQQ absorption by working with a nutrient called coenzyme Q10 (CoQ10). CoQ10 enhances cellular energy production in your mitochondria.[9] Take one ampule up to four times per day.

5. Acetyl-L-carnitine

Acetyl-L-carnitine supplement

Also known as ALC or ALCAR, this brain-enhancing amino acid works by crossing the blood-brain barrier and acting as a powerful antioxidant.

Studies have found that this longevity supplement improves brain function, lowers inflammation, improves blood flow, raises mental and physical energy and even improves your focus.[10] [11] [12] [13] [14] [15]

How to take it: Start with 1 gram per day and work your way up to 2 grams per day. Read more about acetyl-L-carnitine benefits.

6. Whey protein

Whey protein supplement

Whey protein isn’t just for bodybuilders. It gives your liver all the amino acids it needs to build glutathione, your body’s master antioxidant.[16] [17] Glutathione helps your liver neutralize toxins (from your environment, food and cells). It supports your all-important mitochondria, and it also boosts immunity and brain function.

Whey protein is readily available and easy to incorporate into your best anti-aging supplement stack, which is why I recommend it when people ask about dietary supplements. It’s like collagen protein: You’d be missing out on a huge opportunity to turn back the clock by not taking it.

How to take it: Even though you can find whey protein in basically any grocery store, be picky with your protein. Avoid whey protein isolate. The heating and refinement process destroys key nutrients, making it pretty useless—and it doesn’t support glutathione production.

Instead, choose cold-processed, undenatured, grass-fed whey protein, and don’t heat it before eating it. Use 2 tablespoons per day, or up to 4 if you’re working out. Learn more about how to choose the best protein powder for your body.

More Supplements From Bulletproof

Two flavors of Bulletproof Collagen Protein
Can I Take Too Much Collagen in One Day?
A scoop of Greens powder going into a glass of water
What Are Greens? 6 Things to Look for in a Greens Powder Supplement
Man working at home at table
What Are Brain Supplements? What to Know About Nootropics
An overhead shot of different Bulletproof supplements and gummy vitamins
The Bulletproof Guide to Supplements

7. Polyphenols

Blueberries for polyphenol anti-aging supplements

Polyphenols are antioxidants that are naturally found in brightly colored foods like red cabbage, cacao, blueberries and coffee. There are two classes of polyphenols: flavonoids and phenolic acids. They protect your brain from stress and free radical damage, support learning and memory and may help slow down brain aging—which means they’re a big deal for anti-aging.[18] [19] [20] [21]

However, you’d have to eat a wide range of plants every day to reap as many benefits from polyphenols as possible. While you should eat a variety of brightly colored vegetables anyway, a broad-spectrum polyphenol supplement will give you more bang for your buck—and it’s way more efficient than loading up on a bushel of red cabbage.

How to take it: Bulletproof Polyphenomenal contains 1,770mg per serving of nine different polyphenol-rich berries and botanicals. Take four capsules daily.

8. KetoPrime

hand pouring KetoPrime supplement

Bad news: Stress is everywhere. Your brain releases a neurotransmitter called glutamate in response to stress and common environmental toxins, like pesticides.

Glutamate can make you feel unfocused, foggy and definitely not Bulletproof. In rodent studies, researchers found that a compound called oxaloacetate (OAA) protects rodents from glutamate-induced brain damage.[22]

OAA is the active ingredient in Bulletproof KetoPrime, and it’s a great way to help your brain by supporting mitochondrial energy production. Animal studies show that OAA may mimic the effect of calorie restriction, which can boost the production of mitochondria.

How to take it: One KetoPrime lozenge, taken up to five times per day as needed.

9. D-Ribose

Spoonful of D-Ribose

Also called ribose, D-ribose is pretty sweet—and that’s not just because it’s a simple sugar. Your body metabolizes D-ribose differently than other sugars. It’s used to make adenosine triphosphate (ATP), the main energy-carrying molecule in your cells. What does that have to do with your lifespan? D-ribose increases ATP levels in your heart cells, which strengthens your heart so it can keep pumping strong.[23]

How to take it: Use it 1:1 like regular table sugar in your coffee or baked goods.

10. Zinc and copper

Bulletproof zinc with Copper on desk

These essential minerals are important on their own, but I take them together because they complement each other so well. Zinc supports healthy immune function, energy production and mood. When it’s paired with copper, it forms a powerful antioxidant called copper-zinc superoxide dismutase (CuZnSOD).

Most people are deficient in copper, so you should consider adding it to your supplement stack anyway.[24]

How to take it: Take one capsule of Bulletproof Zinc with Copper daily. When taken on an empty stomach, zinc may cause mild stomach discomfort. If this occurs, it is okay to take with a meal, but is best to avoid foods/supplements containing iron, calcium and phytates, because they reduce the bioavailability and absorption of zinc.

11. Vitamins A-D-K

Bulletproof Vitamins A-D-K on counter next to softgel

These vitamins work together to support your immune system, heart and bones. Here’s how:

  • Also called the sunshine vitamin, vitamin D acts on over 1,000 different genes and assists in calcium metabolism and bone formation.
  • Vitamin K helps transport calcium from your bloodstream into your bones.
  • Vitamin A works with vitamin D to support your immune system.

Think of A-D-K as a triple-threat to combat aging—and an easy win in your anti-aging supplement toolkit.

How to take it: Take one softgel of Bulletproof Vitamins A-D-K daily with food.

12. Curcumin

Turmeric root on plate

Curcumin is the compound in turmeric that gives the root its vibrant yellow color. It supports a healthy inflammation response, which is great news as you age because daily activities like exercise can cause baseline levels of inflammation. Although you could theoretically eat a ton of turmeric root to reap the benefits of curcumin, you’re better off using a curcumin supplement. That’s because supplementation is an easy way to ensure you’re getting more bioavailable doses of what you really want from that turmeric root.

How to take it: Two softgels daily of Bulletproof Curcumin Max, with food.

13. Apigenin

Celery juice and stalk

Apigenin is the same compound found in celery juice. In animal research, apigenin was found to improve digestion by helping move food through the gut.[25] Apigenin also helps protect your cells and preserve brain structure and function so you can turn back the clock on the aging process.

How to take it: Apigenin is an ingredient in Bulletproof Smart Mode. Take three softgels daily—no celery juice required.

What about other anti-aging supplements?

Pills on blue background

You can get a slew of anti-aging benefits from other nutrients, like omega-3 fatty acids and vitamin E. This list is based on my own experience with targeted longevity supplements. This isn’t to say that all other anti-aging supplements are bogus.

(Actually, there’s one obvious exception I’ll make here: anti-aging supplements made from endangered animals are totally bogus. Seriously. There’s no known mechanism of action to support powdered rhinoceros horn, and it’s enormously unethical and gross.)

Broadly speaking, everyone has different biochemical makeups, which means your results may vary. Do your research, make sure you’re getting your supplements from a reputable, transparent source and set yourself up for success.

What do I mean? Well, these are just supplements, which means they should supplement the actions you’re already taking to support your health and wellness. To start, get high-quality sleep, eat a low-toxin, anti-inflammatory diet and manage your stress, to start. These behaviors aren’t as easy as taking a multivitamin, but they’re such important actions that you need to treat them like the foundation of your anti-aging stack.

Everything else is just an extra boost to give your brain, body and mitochondria an edge. And when you feel yourself tap into your full potential, you’re going to want to keep going.

Join the Bulletproof Revolution

Sign up for early access to sales, product launches, the latest Bulletproof news and more!

This article has been updated with new content.

Statements made on this website have not been evaluated by the U.S. Food and Drug Administration. Products sold on this website are not intended to diagnose, treat, cure, or prevent any disease. Information provided by this website or this company is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Bulletproof recommends that you consult with your healthcare providers regarding the diagnosis and treatment of any disease or condition.

About Dave Asprey

Dave Asprey is founder of Bulletproof, and creator of the widely-popular Bulletproof Coffee. He is a two-time New York Times bestselling author, host of the Webby award-winning podcast Bulletproof Radio, and has been featured on the Today show, Fox News, Nightline, Dr. Oz, and many more.

References

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/
[3] https://www.ncbi.nlm.nih.gov/pubmed/28842432
[4] https://www.nature.com/articles/s41467-018-03421-7
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212345/
[6] https://www.ncbi.nlm.nih.gov/pubmed/15770429
[7] https://www.sciencedirect.com/science/article/pii/S095528631...
[8] https://www.ncbi.nlm.nih.gov/pubmed/17685628
[9] http://www.jbc.org/content/280/22/21295.long
[10] https://www.ncbi.nlm.nih.gov/pubmed/17658628
[11] https://www.ncbi.nlm.nih.gov/pubmed/20098226
[12] https://www.ncbi.nlm.nih.gov/pubmed/21701126
[13] https://www.ncbi.nlm.nih.gov/pubmed/18993165
[14] https://www.ncbi.nlm.nih.gov/pubmed/12213433
[15] https://www.ncbi.nlm.nih.gov/pubmed/15039515
[16] https://www.tandfonline.com/doi/abs/10.1080/0963748070125358...
[17] https://www.ncbi.nlm.nih.gov/pubmed/1782728
[18] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775888/
[19] https://www.ncbi.nlm.nih.gov/pubmed/20955649
[20] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775887/
[21] https://www.ncbi.nlm.nih.gov/pubmed/26561075
[22] https://www.ncbi.nlm.nih.gov/pubmed/24149933
[23] https://www.ncbi.nlm.nih.gov/pubmed/19641697
[24] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637704/
[25] https://www.ncbi.nlm.nih.gov/pubmed/19427869

TAGS

Anti AgingBiohackingLongevityNootropicsSupplements

Related Bulletproof Supplements

Two flavors of Bulletproof Collagen Protein
Can I Take Too Much Collagen in One Day?
A scoop of Greens powder going into a glass of water
What Are Greens? 6 Things to Look for in a Greens Powder Supplement
Man working at home at table
What Are Brain Supplements? What to Know About Nootropics
An overhead shot of different Bulletproof supplements and gummy vitamins
The Bulletproof Guide to Supplements
Stay Bulletproof: Subscribe Today
SHOP
  • Coffee
  • MCT Oils
  • Proteins
  • Food & Drink
  • Supplements
  • Other
  • All Products
Learn
  • Bulletproof for Beginners
  • Recipes
  • Newsletters & Guides
  • Bulletproof Blog
  • Books
CUSTOMER CARE
  • Contact Us
  • Shipping Policy
  • Return Policy
  • Accessibility Policy
COMPANY
  • About Us
  • Press
  • Careers
  • Customer Reviews
PARTNERS
  • Store Locator
  • Wholesale
  • Ambassador Program
  • Affiliate Program
Nutrition Reimagined

We're reinventing what it means to fuel your mind and body.

  • Facebook
  • Twitter
  • Instagram
  • YouTube

†Statements made on this website have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Information provided by this website or this company is not a substitute for individual medical advice. | ©Bulletproof 360, Inc. 2013–2022

  • Privacy Policy |
  • Terms |
  • Reseller Policy |