13 Anti-Aging Supplements to Turn You Into Benjamin Button
By: Dave Asprey
December 7, 2020
- I plan to live to 180, and my anti-aging supplement stack is one of the ways I’m going to make that happen.
- Below, you’ll find 13 of the best anti-aging supplements to help you turn back the clock. Two things you’ll notice with almost all of these recommendations is that they increase mitochondrial function and protect your cells.
- You can get those same results from other actions, like improving your sleep quality and eating low-toxin, nutrient-dense foods. Longevity supplements just give your brain, body, and cells an extra edge.
It’s no secret that I plan to live 180, and my anti-aging supplement stack is one of the ways I’m going to make that happen. Too many people think that aging involves forgetting your name and leaving your car keys in the fridge. It doesn’t have to be that way. Specific anti-aging supplements help you turn back the clock so you can keep kicking butt and taking names for years to come. Here are my top recommendations to keep your brain going strong.
13 best anti-aging supplements
Fisetin is a plant chemical with profound antioxidant properties. Like other antioxidants, it helps protect your cells from free radicals. Why does that matter? Free radicals are caused by oxidative stress from factors like your diet, environment and sleep routine (or lack thereof). Over time, free radicals can impair cellular function, contribute to cellular damage and accelerate the effects of aging.
That’s why you want plenty of diverse antioxidants in your diet—they help banish free radicals and keep you in fighting shape.
How to take it: Bulletproof Smart Mode contains fisetin, plus a blend of cognitive-enhancing ingredients for total mental clarity. Fisetin is also found naturally in apples, persimmons, onions, and other plants. You can get an abundant dose of fisetin in strawberries. Try this Bulletproof Strawberry Milkshake With Collagen Protein. Speaking of collagen protein…
2. Collagen protein
Collagen supplements may seem like an obvious addition to your anti-aging supplement stack, but it’s worth repeating because collagen is the most abundant protein in the body. It gives structure to your skin, bones, muscles and connective tissue. It reduces fine lines and wrinkles, and improves the elasticity of your skin.
Collagen protein has too many benefits to keep it out of your anti-aging supplement stack. You produce less collagen as you age, so you want to get plenty of it in your diet. Collagen is naturally found in bone broth; pork, salmon and chicken skins; egg yolk and eggshell membranes; and pieces of meat like tendon, tripe and oxtail.
How to take it: You probably don’t eat enough of it, so use a collagen peptides supplement from grass-fed cows. Bulletproof Collagen Protein provides building blocks to support healthy skin, bones and joints, and it mixes easily into coffee and smoothies.
3. Nicotinamide riboside
One thing you’ll notice with almost all of these recommendations is that they increase the performance of your mitochondria—you know, the powerhouses of your cells. Nicotinamide riboside, a form of vitamin B, is a great longevity supplement. It protects your brain from toxins and stress and increases the ratio of two essential compounds called NAD+ and NADH.  Your body uses NAD+ to protect your cells, maintain healthy sleep cycles and repair damaged DNA.
How to take it: In my experience using nicotinamide riboside, I found that you need to take a lot of it, like 1-2 grams, in order to really feel an effect. If the cost of nicotinamide riboside is prohibitive, you have other options. We rigorously selected the formulation in Bulletproof Unfair Advantage to support mitochondrial efficiency with CoQ10 and PQQ.
Pyrroloquinoline quinone, or PQQ, is at the forefront of anti-aging science. It’s a micronutrient that acts as a potent antioxidant, protecting your cells from damaging free radicals and supporting your brain and heart. Studies show that PQQ supports learning and memory, protects your heart, and supports a healthy inflammation response.  
It’s naturally found in some foods like green tea and green peppers, but to reap its anti-aging benefits, take it in supplement form so you get a high enough dose that actually absorbs into your bloodstream.
How to take it: The main ingredient in Bulletproof Unfair Advantage is ActivePQQ, which is specifically designed to improve PQQ absorption by working with a nutrient called coenzyme Q10 (CoQ10). CoQ10 enhances cellular energy production in your mitochondria. Take one ampule up to four times per day.
Also known as ALC or ALCAR, this brain-enhancing amino acid works by crossing the blood-brain barrier and acting as a powerful antioxidant.
Studies have found that this longevity supplement improves brain function, lowers inflammation, improves blood flow, raises mental and physical energy and even improves your focus.     
How to take it: Start with 1 gram per day and work your way up to 2 grams per day. Read more about acetyl-L-carnitine benefits.
6. Whey protein
Whey protein isn’t just for bodybuilders. It gives your liver all the amino acids it needs to build glutathione, your body’s master antioxidant.  Glutathione helps your liver neutralize toxins (from your environment, food and cells). It supports your all-important mitochondria, and it also boosts immunity and brain function.
Whey protein is readily available and easy to incorporate into your best anti-aging supplement stack, which is why I recommend it when people ask about dietary supplements. It’s like collagen protein: You’d be missing out on a huge opportunity to turn back the clock by not taking it.
How to take it: Even though you can find whey protein in basically any grocery store, be picky with your protein. Avoid whey protein isolate. The heating and refinement process destroys key nutrients, making it pretty useless—and it doesn’t support glutathione production.
Instead, choose cold-processed, undenatured, grass-fed whey protein, and don’t heat it before eating it. Use 2 tablespoons per day, or up to 4 if you’re working out. Learn more about how to choose the best protein powder for your body.
Polyphenols are antioxidants that are naturally found in brightly colored foods like red cabbage, cacao, blueberries and coffee. There are two classes of polyphenols: flavonoids and phenolic acids. They protect your brain from stress and free radical damage, support learning and memory and may help slow down brain aging—which means they’re a big deal for anti-aging.   
However, you’d have to eat a wide range of plants every day to reap as many benefits from polyphenols as possible. While you should eat a variety of brightly colored vegetables anyway, a broad-spectrum polyphenol supplement will give you more bang for your buck—and it’s way more efficient than loading up on a bushel of red cabbage.
How to take it: Bulletproof Polyphenomenal contains 1,770mg per serving of nine different polyphenol-rich berries and botanicals. Take four capsules daily.
Bad news: Stress is everywhere. Your brain releases a neurotransmitter called glutamate in response to stress and common environmental toxins, like pesticides.
Glutamate can make you feel unfocused, foggy and definitely not Bulletproof. In rodent studies, researchers found that a compound called oxaloacetate (OAA) protects rodents from glutamate-induced brain damage.
OAA is the active ingredient in Bulletproof KetoPrime, and it’s a great way to help your brain by supporting mitochondrial energy production. Animal studies show that OAA may mimic the effect of calorie restriction, which can boost the production of mitochondria.
How to take it: One KetoPrime lozenge, taken up to five times per day as needed.
Also called ribose, D-ribose is pretty sweet—and that’s not just because it’s a simple sugar. Your body metabolizes D-ribose differently than other sugars. It’s used to make adenosine triphosphate (ATP), the main energy-carrying molecule in your cells. What does that have to do with your lifespan? D-ribose increases ATP levels in your heart cells, which strengthens your heart so it can keep pumping strong.
How to take it: Use it 1:1 like regular table sugar in your coffee or baked goods.
10. Zinc and copper
These essential minerals are important on their own, but I take them together because they complement each other so well. Zinc supports healthy immune function, energy production and mood. When it’s paired with copper, it forms a powerful antioxidant called copper-zinc superoxide dismutase (CuZnSOD).
Most people are deficient in copper, so you should consider adding it to your supplement stack anyway.
How to take it: Take one capsule of Bulletproof Zinc with Copper daily. When taken on an empty stomach, zinc may cause mild stomach discomfort. If this occurs, it is okay to take with a meal, but is best to avoid foods/supplements containing iron, calcium and phytates, because they reduce the bioavailability and absorption of zinc.
11. Vitamins A-D-K
These vitamins work together to support your immune system, heart and bones. Here’s how:
- Also called the sunshine vitamin, vitamin D acts on over 1,000 different genes and assists in calcium metabolism and bone formation.
- Vitamin K helps transport calcium from your bloodstream into your bones.
- Vitamin A works with vitamin D to support your immune system.
Think of A-D-K as a triple-threat to combat aging—and an easy win in your anti-aging supplement toolkit.
How to take it: Take one softgel of Bulletproof Vitamins A-D-K daily with food.
Curcumin is the compound in turmeric that gives the root its vibrant yellow color. It supports a healthy inflammation response, which is great news as you age because daily activities like exercise can cause baseline levels of inflammation. Although you could theoretically eat a ton of turmeric root to reap the benefits of curcumin, you’re better off using a curcumin supplement. That’s because supplementation is an easy way to ensure you’re getting more bioavailable doses of what you really want from that turmeric root.
How to take it: Two softgels daily of Bulletproof Curcumin Max, with food.
Apigenin is the same compound found in celery juice. In animal research, apigenin was found to improve digestion by helping move food through the gut. Apigenin also helps protect your cells and preserve brain structure and function so you can turn back the clock on the aging process.
How to take it: Apigenin is an ingredient in Bulletproof Smart Mode. Take three softgels daily—no celery juice required.
What about other anti-aging supplements?
You can get a slew of anti-aging benefits from other nutrients, like omega-3 fatty acids and vitamin E. This list is based on my own experience with targeted longevity supplements. This isn’t to say that all other anti-aging supplements are bogus.
(Actually, there’s one obvious exception I’ll make here: anti-aging supplements made from endangered animals are totally bogus. Seriously. There’s no known mechanism of action to support powdered rhinoceros horn, and it’s enormously unethical and gross.)
Broadly speaking, everyone has different biochemical makeups, which means your results may vary. Do your research, make sure you’re getting your supplements from a reputable, transparent source and set yourself up for success.
What do I mean? Well, these are just supplements, which means they should supplement the actions you’re already taking to support your health and wellness. To start, get high-quality sleep, eat a low-toxin, anti-inflammatory diet and manage your stress, to start. These behaviors aren’t as easy as taking a multivitamin, but they’re such important actions that you need to treat them like the foundation of your anti-aging stack.
Everything else is just an extra boost to give your brain, body and mitochondria an edge. And when you feel yourself tap into your full potential, you’re going to want to keep going.
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This article has been updated with new content.