Aging Formula Science Research
Aging Formula - What does Science and Research Say
Oxaloacetate Gives You The Advantages of Caloric Restriction (without restricting calories)
Oxaloacetate is a calorie restriction mimetic. It takes advantage of the benefits of calorie restriction while saving you from the negatives. In animals, calorie restriction can extend lifespan by up to 50%.
There is little question calorie restriction extends life in animals, but it can cause problems for humans like low body temperature, muscle loss, cognitive dysfunction, and decreased quality of life. This dilemma has led researchers to look for substances that mimic the effects of calorie restriction, while avoiding the side effects.
Oxaloacetate is the most promising substance we’ve yet found. It extends lifespan in worms and rodents by triggering the same effects as caloric restriction. By mimicing caloric restriction without its harmful effects, oxaloacetate has a plethora of health benefits, many of which we are just beginning to understand.
Oxaloacetate is thought to work by protecting neurons from harmful amounts of glutamate, and protecting mitochondria from DNA damage due to environmental toxins. Oxaloacetate may also support health in age-related conditions.
Oxaloacetate Programs Your Genes for Maximum Longevity
Animal models show that oxaloacetate tells genes to keep you alive longer than would normally be possible. Activating the AMPK-FOXO pathways through calorie restriction extends lifespan in worms. In vitro, oxaloacetate can increase NAD+ levels by 50%, which activates the AMPK-FOXO pathways. Oxaloacetate may potentially support an increase lifespan.
Why Your Brain is in Danger (and How Oxaloacetate Can Help)
Oxaloacetate maintains healthy neurons in your brain and nervous system by insuring that there is no toxic build-up of glutamate in your head.(+)
Glutamate is the most common neurotransmitter in your body. Monosodium glutamate (MSG) also raises glutamate levels in the human body. It is needed for learning and memory, but under the wrong conditions, it can kill neurons.
In excess, glutamate excites your brain cells to death, which can lead to serious problems including cognitive decline. In particular, glutamate kills the cells that make myelin, the coating around your nerves that is needed for the creation of white matter.
When everything is working right, glutamate levels in the brain are kept in a fine balance, with just enough being produced to support brain function without causing harm. However, chronic stress impairs glutamate metabolism so that excess glutamate accumulates in the brain.
Over time, excess glutamate can cause mental impairment, sleep problems, and even more stress, all of which impairs glutamate recycling. This becomes a vicious cycle where stress leads to glutamate toxicity, and glutamate toxicity leads to more stress. Oxaloacetate supports healthy glutamate metabolism, supporting appropriate brain function.
Oxaloacetate Protects You From Brain Damage and Supports Your Mitochondria
Oxaloacetate steps in and keeps glutamate from wreaking havoc on your brain. Not only does it reduce glutamate levels, it converts the harmful excess glutamate into fuel for neurons.
Injecting rats with oxaloacetate also reduced glutamate levels and protected neurons after traumatic head injury. This results in improved brain function over the long term. On the flip side, when oxaloacetate metabolism is blocked in animals that suffer a stroke, brain damage is far more severe.
Even though most studies on Oxaloacetate are done in animal studies, Oxaloacetate shows a lot of promise for supporting and maintaining proper neurological function. For our purposes, we use it to clear brain fog that can result from stress and glutamate buildup, and provide neurological support for smoother thought processes and performance. Please remember to consult with your licensed healthcare provider, first, before taking this product if you have had a traumatic head injury or have suffered a stroke.
Supports Your Mitochondria
Damage to mitochondrial DNA is a major contributor to aging and other serious conditions. Loss of brain function is often preceded by a decline in mitochondrial function.
In vitro studies have shown that oxaloacetate protects against mitochondrial DNA damage from environmental toxins. Oxaloacetate also supports your DNA by increasing NAD+ levels in your cells, which shields DNA from free radical damage. In rats, oxaloacetate can reduce mitochondrial damage caused by excitotoxins.
Oxaloacetate has also been shown to increase the protective effects of zinc on human eye cells in a test tube. By supporting your DNA and other tissues, oxaloacetate may reduce your risk of many age-related degenerative conditions.
If you want to learn more about oxaloacetate, check out some of our sources below!
- Calorie restriction and prevention of age-associated chronic disease
- Calorie restriction and aging in nonhuman primates
- Nonhuman primate calorie restriction
- Calorie restriction and cardiometabolic health.
- Caloric restriction: powerful protection for the aging heart and vasculature
- Caloric restriction
- Calorie restriction mimetics: an emerging research field
- Development of calorie restriction mimetics as a prolongevity strategy
- Caloric restriction mimetics: the next phase
- Development of Calorie Restriction Mimetics as Therapeutics for Obesity, Diabetes, Inflammatory and Neurodegenerative Diseases
- Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway
- An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
- The permeability of mitochondria to oxaloacetate and malate
- Glutamate as a neurotransmitter in the brain: review of physiology and pathology
- Glutamate: its role in learning, memory, and the aging brain
- Glutamate in brain: transmitter and poison
- Glutamate and ATP signalling in white matter pathology
- Role of excitatory amino acids in neuropathology
- The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
- Brain neuroprotection by scavenging blood glutamate
- Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke
- Oxaloacetate decreases the infarct size and attenuates the reduction in evoked responses after photothrombotic focal ischemia in the rat cortex
- Effect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in rats
- The neuroprotective effects of oxaloacetate in closed head injury in rats is mediated by its blood glutamate scavenging activity: evidence from the use of maleate
- Oxaloacetate restores the long-term potentiation impaired in rat hippocampus CA1 region by 2-vessel occlusion
- Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study
- Oxaloacetate: a novel neuroprotective for acute ischemic stroke
- Blood levels of glutamate oxaloacetate transaminase are more strongly associated with good outcome in acute ischaemic stroke than glutamate pyruvate transaminase levels
- High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke
- Studies on the anti-diabetic effect of sodium oxaloacetate
- Stereochemistry and function of oxaloacetate keto-enol tautomerase
- Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cells
- Brain amino acid metabolism and ketosis
- Zinc and energy requirements in induction of oxidative stress to retinal pigmented epithelial cells
- Differential modulation of intracellular energetics in A549 and MRC-5 cells